The basis of this article examines the impacts of social, political and religious movements through a multi-layered study of the Dancing Plague in Strasbourg from the early 1200s to the early 1500s. Analyzing this historic, yet rather strange dancing hysteria, these movements created severe forms of depression, stress and anxiety which ultimately led to high levels of psychosis within the community. The time period studied includes the Bundschuh riots and the peasants' seizure of Strasbourg citizenship, religious justifications for disease and the emergence of powerful saints, and severe hunger strikes resulting from years of failed harvests and climate change anomalous. This analysis uses several important sermons by Lutheran theologians such as Matthäus Zell and Martin Bucer, eyewitness accounts of those present in Strasbourg before, during and after the dancing plague, and medical reports by Strasbourg doctor Johann Widmann. Likewise, this study challenges the pre-Reformation argument that the Dancing Plague was a form of punishment sent by God, but rather induced through biological and psychological means. The various movements in Strasbourg contested the inequalities and injustices of the Church towards the peasants, which created harsh and impossible living conditions for the peasants. This in turn led some four hundred citizens to dance feverishly in the streets of Strasbourg in the summer of 1518. Located on the southeastern border of the Holy Roman Empire, Strasbourg flourished as an important agricultural market and transportation center. The region's landscape provided balance between the two most important natural resources: grain and wine. The plains abundantly provided the city with... paper halves... specifically designated areas within the city that were prohibited from wearing luxury accessories. Likewise, gamblers were forced to mingle with card and dice players in gambling dens. The following year's crops improved greatly, which strengthened the belief that the city had been divinely rewarded for cleansing the city. However, the excitement was short-lived when Europe was struck by syphilis. The first recognized news of the disease was on 22 February 1495 during King Charles VIII's invasion of Naples. Syphilis crept into Strasbourg via mercenary pikes, or Landsknechts, returning from the Italian wars and came into contact with Spanish troops who had sexual relations with prostitutes. In the spring of that year the city's chief executive, or ammsister, reported having a "bad pox" never before seen in the city.