IntroductionThe Centers for Disease Control and Prevention (CDC) defines multidrug-resistant organisms (MDROs) “as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents" ("Management of Multidrug-Resistant Organisms", 2006). The following list represents the widely known MDROs: MSSA, or “Methicillin-susceptible Staphylococcus aureus,” which responds well to typical antibiotics; MRSA, or “Methicillin-resistant Staphylococcus aureus.” This bacterium is resistant also to oxacillin and cefoxitin drugs; VRE, or "vancomycin-resistant Enterococcus", bacteria resistant to vancomycin drugs; CephR-Klebsiella, "cephalosporin-resistant Klebsiella" or any Klebsiella bacteria resistant to ceftazidime, cefotaxime, ceftriaxone , or cefepime;CRE-Klebsiella, or “Carbapenem-resistant Enterobacteriaceae,” or any Klebsiella bacteria resistant to the drugs mipenem, meropenem, or doripenem;CRE-Ecoli, or “Carbapenem-resistant Enterobacteriaceae,” or any E. coli bacteria resistant to imipenem, meropenem or doripenem drugs; MDR-Acinetobacter, “multidrug-resistant” Acinetobacter bacteria – resistant to at least one agent in at least 3 antimicrobial classes of the following 6 antimicrobial classes: Table 1 (“Multidrug-Resistant Organisms,” 2014). According to the CDC, approximately one in 20 patients hospitalized in the United States will contract a healthcare-associated infection (HAI), many of which are attributed to MDROs(3). The increase in the number of patients becoming infected with MDROs makes prevention and control a priority in hospitals and health centers nationwide. combination…half the paper…water physically displaces bacterial spores that are not reliably killed with alcohol-based products” (9). Hands should be washed for at least 15 seconds, covering all surfaces of the fingers and hands; wash your hands before and after each contact with a patient; before and after wearing sterile gloves; before handling any invasive medical device; after contact with any bodu secretions; after contact with equipment or other objects close to the patient; before eating; after using the bathroom; if bacterial exposure is suspected. Conclusion The increase in MDROs in acute healthcare settings is a real and current benefit to the health and lives of patients and medical staff. Understanding possible complications, promoting education at all levels, and strictly adhering to safe cleaning measures play a crucial role in the management of MDROs and their prevention, as well as mortality rates and associated costs.