The Centers for Disease Control and Prevention (CDC), describes antibiotic resistance as the ability of bacteria or other microbes to resist the effects of antibiotic treatment. () So, instead of being destroyed by drugs, the bacteria survive and continue to reproduce, giving rise to new communicable diseases that are even more difficult to treat. Because of this problem, the CDC established a campaign titled "Campaign to Prevent Antimicrobial Resistance." " The campaign focuses on four integrated strategies: preventing infection, diagnosing and treating infection effectively, using antimicrobials wisely, and preventing transmission.() This campaign consists of 12 steps that teach nurses and other providers health care providers and present plans to advance nursing practice as well as antimicrobial use. Another campaign developed by the CDC is the Transatlantic Task Force on Antimicrobial Resistance (TATFAR). Appropriate therapeutic use of antimicrobial drugs in the medical and veterinary communities Additionally, prevention of drug-resistant infections in both healthcare-associated and community settings and strategies to improve the pipeline of new antimicrobial drugs() Explains mechanisms of action in detail. underlying factors that are the basis of the pharmacological action. Acquired antimicrobial resistance can generally be ascribed to one of five mechanisms. These include the production of enzymes that inactivate the drug, modification of an existing target, acquisition of a target bypass system, reduced cell permeability, and removal of the drug from the cell. (Sefton) Even a bacterium that was once antibiotic-prone can acquire resistance through alt...... middle of paper ......and forced. Dosing medications and adopting proper methods around the clock also help prevent resistance. According to Karch, around-the-clock dosing helps eliminate peaks and valleys in drug concentration and helps maintain consistent therapeutic levels. Summary Nurses should take a leading role in reducing the impact of disease on patients and influencing the expansion of evidence-based infection prevention practice. Prevention of antimicrobial resistance must remain a huge priority. In times of conflicting priorities regarding patient safety, progress has been made in the fight against these bacteria and infections. The prospect of a near future without useful antibiotics should not be ignored, and all of us in positions of influence should seriously encourage and educate about the conscientious use of antimicrobials and do everything we can to prevent the situation from spreading..